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Carol B. Fowler
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Former Member
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Lake Superior |
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Phone: none
fowler2@niehs.nih.gov
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B.S.:
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Chemistry Erskine College, Due West, SC, 1994
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Ph.D.:
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Medicinal Chemistry, University of Michigan, MI, 2002
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Research Interests
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Protein engineering.
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GPCR expression.
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Peptide synthesis.
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HPLC.
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Selected Publications
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Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR
Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.
Biochem. Biophys. Res. Commun., 293: 1233-1241 (2002)
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Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.
Biochemistry, 41: 1223-1241 (2002)
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Fowler CB,. Pogozheva ID, Akil H, LeVine III H, Mosberg HI
Determination of the relative positions between TMH V and VI of the mu-opioid receptor using site-directed mutagenesis
Peptides for the New Millennium, Proceedings of the 16th American Peptide Symposium: 374-375 (2000)
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Mosberg HI, Fowler CB
Development and validation of opioid ligand-receptor interaction models: The structural basis of mu vs. delta selectivity
J. Peptide Res., 60: 329-332 (2002)
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Fowler CB, Pogozheva ID, LeVine H 3rd, Mosberg HI.
Refinement of a homology model of the mu-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites.
Biochemistry., 43: 8700-8710 (2004)
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Fowler CB, Pogozheva ID, Lomize AL, LeVine H, Mosberg HI
Complex of active mu-opioid receptor with cyclic peptide agonist modeled from experimental constraints.
Biochemistry, 43: 15796-15810 (2004)
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