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Irina D.Pogozheva
Associate Research Scientist
UofM Directory
Finger Information
Phone: (734)647-5825
Department of Biophysics, Moscow State University, Moscow, Russia (1979 Biology, Biophysics)
Semenov Institute of Chemical Physics, Russian Academy of Science, Moscow (1985, Biophysics)

Research Interests

Structure prediction of membrane proteins.

Modeling of protein-protein and ligand-protein interactions.


Homology modeling of GPCRs, important drug targets

Peptides and proteins in membranes

Selected Publications

Lomize A.L., Pogozheva I.D.
TMDOCK: An energy-based method for modeling α-helical dimers in membranes.
J Mol Biol, 429: pii: S0022-2836(16)30369-2 [Epub] (2017)


Lomize A.L., Lomize M.A., Krolicki S.R., Pogozheva I.D.
Membranome: a database for proteome-wide analysis of single-pass membrane proteins.
Nucleic Acids Res, 45(D1): pii: gkw712 [Epub] (2017)


Harland A.A., Bender A.M., Griggs N.W., Gao C., Anand J.P., Pogozheva I.D., Traynor J.R., Jutkiewicz E.M., Mosberg H.I.
Effects of N-substitutions on the tetrahydroquinoline (THQ) core of mixed-efficacy mu-opioid receptor (MOR)/delta-opioid receptor (DOR) ligands
J Med Chem, 59: 4985-4998 (2016)


Harland A.A., Yeomans L., Griggs N.W., Anand J.P., Pogozheva I.D., Jutkiewicz E.M., Traynor J.R., Mosberg H.I.
Further optimization and evaluation of bioavailable, mixed-efficacy mu-opioid receptor (MOR) agonists/delta-opioid receptor (DOR) antagonists: balancing MOR and DOR affinities
J Med Chem, 58: 8952-8969 (2015)


Antonenko Y.N., Gluhov G.S., Firsov A.M., Pogozheva I.D., Kovalchuk S.I., Pechnikova E.V., Kotova E.A., Sokolova O.S.
Gramicidin A disassembles large conductive clusters of its lysine-substituted derivatives in lipid membranes
Phys Chem Chem Phys, 17: 17461-17470 (2015)


Geng J., Pogozheva I.D., Mosberg H.I., Raghavan M.
Use of functional polymorphisms to elucidate the peptide binding site of TAP complexes
J Immunol, 196: pii: 1500985 (2015)


Kumar V., Ridzwan I.E., Grivas K., Lewis J.W., Clark M.J., Meurice C., Jimenez-Gomez C., Pogozheva I., Mosberg H., Traynor J.R., Husbands S.M.
Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity
J Med Chem, 57: 4049-4057 (2014)


Pogozheva I.D., Mosberg H.I., Lomize A.L.
Life at the border: adaptation of proteins to anisotropic membrane environment
Protein Sci, 23: 1165-1196 (2014)


Anand J.P., Porter-Barrus V.R., Waldschmidt H.V., Yeomans L., Pogozheva I.D., Traynor J.R., Mosberg H.I.
Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues
Biopolymers, 102: 107-114 (2014)


Pogozheva I.D., Tristram-Nagle S., Mosberg H.I., Lomize A.L.
Structural adaptations of proteins to different biological membranes
Biochim Biophys Acta-Biomembranes, 1828: 2592-2608 (2013)


Lomize A.L., Pogozheva I.D.
Solvation models and computational prediction of orientations of peptides and proteins in membranes
Methods Mol Biol, 1063: 125-142 (2013)


Anand J.P., Purington L.C., Pogozheva I.D., Traynor J.R., Mosberg H.I.
Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models
Chem Biol Drug Des, 80: 763-770 (2012)


Janovick J.A., Pogozheva I.D., Mosberg H.I., Cornea A., Conn P.M.
Rescue of misrouted GnRHR Mutants reveals its constitutive activity
Mol Endocrinol, 26: 1179-1188 (2012)


Lomize M.A., Pogozheva I.D., Joo H., Mosberg H.I., Lomize A.L.
OPM database and PPM web server: resources for positioning of proteins in membranes
Nucleic Acids Res, 40(Database issue): D370-D376 (2012)


Lomize AL, Pogozheva ID, Mosberg HI.
Anisotropic solvent model of the lipid bilayer. 1. Parameterization of long-range electrostatics and first solvation shell effects.
J Chem Inf Model, 51: 918-929 (2011)


Janovick JA, Pogozheva ID, Mosberg HI, Conn PM.
Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for g protein-coupled receptor activation.
J Pharmacol Exp Ther, 338: 430-442 (2011)


Zhang WX, Thakur V, Lomize A, Pogozheva I, Panagabko C, Cecchini M, Baptist M, Morley S, Manor D, Atkinson J.
The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP).
J Mol Biol, 405: 972-988 (2011)


Ho D, Lugo MR, Lomize AL, Pogozheva ID, Singh SP, Schwan AL, Merrill AR.
Membrane topology of the colicin E1 channel using genetically encoded fluorescence.
Biochemistry, 50: 4830-4842 (2011)


Purington L.C., Sobczyk-Kojiro K., Pogozheva I.D., Traynor J.R., Mosberg H.I.
Development and in vitro characterization of a novel bifunctional mu-agonist/delta-antagonist opioid tetrapeptide
ACS Chem Biol, 6: 1375-1381 (2011)


Lomize AL, Pogozheva ID, Mosberg HI.
Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes.
J Chem Inf Model, 51: 930-946 (2011)


René P, Le Gouill C, Pogozheva ID, Lee G, Mosberg HI, Farooqi IS, Valenzano KJ, Bouvier M.
Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity.
J Pharmacol Exp Ther, 335: 520-532 (2010)


Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O Rahilly S, Mosberg HI, Farooqi IS.
Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.
Endocrinology, 150(1): 114-125 (2009)


Purington LC, Pogozheva ID, Traynor JR, Mosberg HI.
Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties.
J Med Chem, 52(23): 7724-7731 (2009)


Haskell-Luevano C, Xiang Z, Wilczynski AM, Haskell KR, Andreasen AM, Litherland SA, Millard WJ, Pogozheva ID, Mosberg HI, Sorenson NB.
Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans.
Adv Exp Med Biol, 611: 509-510 (2009)


Proneth B, Pogozheva ID, Portillo FP, Mosberg HI, Haskell-Luevano C.
Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity.
J Med Chem, 51(18): 5585-5593 (2008)


Lomize AL, Pogozheva ID, Lomize MA, Mosberg HI
The role of hydrophobic interactions in positioning of peripheral proteins in membranes
BMC Struct Biol, 7: 44 (2007)


Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C.
Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms
Biochemistry, 46(28): 8273-8287 (2007)


Lomize MA, Lomize AL, Pogozheva ID, Mosberg HI
OPM: orientations of proteins in membranes database.
Bioinformatics, 22: 623-625 (2006)


Proneth B, Xiang Z, Pogozheva ID, Litherland SA, Gorbatyuk OS, Shaw AM, Millard WJ, Mosberg HI, Haskell-Luevano C
Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism
Chem. Biol. Drug. Des., 67: 215-229 (2006)


Lomize AL, Pogozheva ID, Lomize MA, Mosberg HI
Positioning of proteins in membranes: a computational approach
Protein Sci., 15: 1318-1333 (2006)


Kneen MM, Pogozheva ID, Kenyon GL, McLeish MJ
Exploring the active site of benzaldehyde lyase by modeling and mutagenesis
Biochim. Biophys. Acta, 1753: 263-271 (2005)


Pogozheva ID, Przydzial MJ, Mosberg HI
Homology modeling of opioid receptor-ligand complexes using experimental constraints.
AAPS J., 7: E434-E448 (2005)


Przydzial MJ, Pogozheva ID, Ho JC, Tharp TA, Drankhan KE, Sawyer E, Traynor JR, Mosberg HI
Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors.
J. Pept. Res., 66: 255-262 (2005)


Przydzial MJ, Pogozheva ID, Bosse KE, Andrews SM, Tod A, Tharp TA, Traynor JR, Mosberg HI
Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa- opioid receptor
J. Pept. Res., 65: 333-342 (2005)


Pogozheva ID, Chai B-X, Lomize AL, Fong TM, Weinberg DH, Nargund RH, Mulholland MW, Gantz I, Mosberg HI
Interactions of human melanocortin receptor-4 with small-molecule agonists.
Biochemistry, 44: 11329-11341 (2005)


Chai B-X, Pogozheva ID, Lai Y-M, Li J-Y, Neubig RR, Mosberg HI, Gantz I
Receptor-antagonist interactions in the complexes of agouti protein and agouti-related protein with human melanocortin 1 and 4 receptors.
Biochemistry, 44: 3418-3431 (2005)


Fowler CB, Pogozheva ID, Lomize AL, LeVine H, Mosberg HI
Complex of active mu-opioid receptor with cyclic peptide agonist modeled from experimental constraints.
Biochemistry, 43: 15796-15810 (2004)


Lomize AL, Pogozheva ID, Mosberg HI
Quantification of helix-helix binding affinities in micelles and lipid bilayers.
Protein Sci., 13: 2600-2612 (2004)


Fowler CB, Pogozheva ID, LeVine H 3rd, Mosberg HI.
Refinement of a homology model of the mu-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites.
Biochemistry., 43: 8700-8710 (2004)


Poulsen A, Bjornholm B, Gundertofte K, Pogozheva ID, Liljefors T
Pharmacophore and receptor models for neurokinin receptors.
J. Comput. Aided. Mol. Des., 17: 765-783 (2003)


Munshi UM, Pogozheva ID, Menon KM
Highly conserved serine in the third transmembrane helix of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor activation.
Biochemistry., 42: 3708-3715 (2003)


Lomize AL, Reibarkh MY, Pogozheva ID
Interatomic potentials and solvation parameters from protein engineering data for buried residues.
Protein Sci., 11: 1984-2000 (2002)


Lomize AL, Pogozheva ID, Mosberg HI
Structural organization of G-protein-coupled receptors.
J. Comput. Aided Mol. Des., 13: 325-353 (1999)


Lomize AL, Pogozheva ID, Mosberg HI
Prediction of protein structure: The problem of fold multiplicity.
Proteins, 37: 199-203 (1999)


Pogozheva ID, Lomize AL, Mosberg HI
Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.
Biophys. J., 75: 612-634 (1998)


Pogozheva ID, Lomize AL, Mosberg HI
The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints.
Biophys. J., 72: 1963-1985 (1997)


Mosberg HI, Dua RK, Pogozheva ID, Lomize AL
Development of a model for the delta-opioid receptor pharmacophore. 4. Residue 3dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirmrequired gauche orientation of aromatic side chain.
Biopolymers, 39: 287-296 (1996)


Lomize AL, Pogozheva ID, Mosberg HI
Development of a model for the delta-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH with other conformationally constrained delta-receptor selective ligands.
Biopolymers., 38: 221-234 (1996)


People People
Henry I. Mosberg
Andrei L.Lomize
Irina D.Pogozheva
Katarzyna Sobczyk-Kojiro
Jessica Anand
Anthony F. Nastase
Sean P. Henry
Deanna Montgomery
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