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Jessica Anand
Research Fellow
UofM Directory
Finger Information
Phone: 734-764-7338
janand@umich.edu
 
B.S.:
B.A. Biochemistry, Barnard College, Columbia University, New York, NY (2007)
M.S.:
University of Michigan, Ann Arbor (2009)
Medicinal Chemistry
 

  • Pharmacological Sciences Training Program, Trainee
  • Neuroscience Trainee

Research Interests

Design, synthesis and pharmacological evaluation of fluorescent selective and potent opioid peptides

Confocal microscopy


Projects

Investigations of MOR and DOR trafficking and crosstalk


Selected Publications

Harland A.A., Bender A.M., Griggs N.W., Gao C., Anand J.P., Pogozheva I.D., Traynor J.R., Jutkiewicz E.M., Mosberg H.I.
Effects of N-substitutions on the tetrahydroquinoline (THQ) core of mixed-efficacy mu-opioid receptor (MOR)/delta-opioid receptor (DOR) ligands
J Med Chem, 59: 4985-4998 (2016)

 

Anand J.P., Boyer B.T., Mosberg H.I., Jutkiewicz E.M.
The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice
Psychopharmacology (Berl), 233: 2479-2487 (2016)

 

Bender A.M., Griggs N.W., Anand J.P., Traynor J.R., Jutkiewicz E.M., Mosberg H.I.
Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy mu opioid receptor/delta opioid receptor ligands
ACS Chem Neurosci, 6: 1428-1435 (2014)

 

Mosberg H.I., Yeomans L., Anand J.P., Porter V., Sobczyk-Kojiro K., Traynor J.R., Jutkiewicz E.M.
Development of a bioavailable mu opioid receptor (MOPr) agonist, delta opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance
J Med Chem, 57: 3148-3153 (2014)

 

Anand J.P., Porter-Barrus V.R., Waldschmidt H.V., Yeomans L., Pogozheva I.D., Traynor J.R., Mosberg H.I.
Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues
Biopolymers, 102: 107-114 (2014)

 

Mosberg H.I., Yeomans L., Harland A.A., Bender A.M., Sobczyk-Kojiro K., Anand J.P., Clark M.J., Jutkiewicz E.M., Traynor J.R.
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy mu opioid receptor (MOR) agonist/delta opioid receptor (DOR) antagonist ligands
J Med Chem, 56: 2139-2149 (2013)

 

Anand J.P., Purington L.C., Pogozheva I.D., Traynor J.R., Mosberg H.I.
Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models
Chem Biol Drug Des, 80: 763-770 (2012)

 

Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK.
Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.
J Biol Chem, 284(39): 26732-26741 (2009)

 

People People
Henry I. Mosberg
Andrei L.Lomize
Irina D.Pogozheva
Katarzyna Sobczyk-Kojiro
Jessica Anand
Anthony F. Nastase
Sean P. Henry
Deanna Montgomery
Projects Projects
Publications Publications
Resources Resources


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