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Larisa Yeomans
Former Member
  • UMSARC/NIDA postdoctoral training fellowship, 2010-2012
UofM Directory
Finger Information
Phone: 734-764-7338
yeomans@umich.edu
 
B.S.:
Instituto Tecnologico y de Estudios Superiores de Monterrey, Monterrey, NL. Mexico (1999)
Major: Chemistry
Minor: Polymers
Ph.D.:
Organic Chemistry, University of Arizona, Tucson, AZ (2009)
 

Research Interests

Design, synthesis and characterization of MOR/DOR opioid peptidomimetics and glycopeptides

Pharmacological testing of synthesized compounds

Medicinal chemistry, organic synthesis, peptide synthesis, carbohydrate synthesis, glycosylated aminoacid synthesis

NMR and molecular modeling

Peptide-membrane interactions


Selected Publications

Harland A.A., Yeomans L., Griggs N.W., Anand J.P., Pogozheva I.D., Jutkiewicz E.M., Traynor J.R., Mosberg H.I.
Further optimization and evaluation of bioavailable, mixed-efficacy mu-opioid receptor (MOR) agonists/delta-opioid receptor (DOR) antagonists: balancing MOR and DOR affinities
J Med Chem, 58: 8952-8969 (2015)

 

Mosberg H.I., Yeomans L., Anand J.P., Porter V., Sobczyk-Kojiro K., Traynor J.R., Jutkiewicz E.M.
Development of a bioavailable mu opioid receptor (MOPr) agonist, delta opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance
J Med Chem, 57: 3148-3153 (2014)

 

Anand J.P., Porter-Barrus V.R., Waldschmidt H.V., Yeomans L., Pogozheva I.D., Traynor J.R., Mosberg H.I.
Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues
Biopolymers, 102: 107-114 (2014)

 

Mosberg H.I., Yeomans L., Harland A.A., Bender A.M., Sobczyk-Kojiro K., Anand J.P., Clark M.J., Jutkiewicz E.M., Traynor J.R.
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy mu opioid receptor (MOR) agonist/delta opioid receptor (DOR) antagonist ligands
J Med Chem, 56: 2139-2149 (2013)

 

People People
Henry I. Mosberg
Andrei L.Lomize
Irina D.Pogozheva
Katarzyna Sobczyk-Kojiro
Jessica Anand
Anthony F. Nastase
Sean P. Henry
Deanna Montgomery
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